ÖZET
Sonuç:
Bu çalışma COE’nin ve hyalurinik asitli adezyon bariyerinin her ikisininde scraping modelli ratlarda postoperatif intraabdominal adezyonların insidansını önemli derecede azalttığını göstermiştir. Mekanizma açık olmamasına rağmen peritoneal kaviteye uygulanan COE adezyon gelişimini azaltmıştır. COE ile hyaluronik asitli adezyon bariyerinin arasında adezyonu önleme açısından istatistiksel anlamlı bir fark bulunamamıştır. Ancak COE maliyet açısından hyaluronik asitli adezyon bariyerinden daha çok avantajlı olmasına rağmen insanlar üzerinde uygulanmadan önce toksikoloji çalışmaları mutlaka yapılmalıdır.
Bulgular:
Gruplar arasında makroskopik adezyon skorlaması açısından istatistiksel olarak anlamlı fark bulunamadı. Histopatolojik inceleme neticesinde mikroskopik adezyon skorları karşılaştırıldığında grup 1 ile 2 arasındaki istatistiksel fark p=0,044 olup anlamlıydı. Grup 1 ve 3 karşılaştırıldığında p=0,010 olup istatistiksel olarak anlamlıydı. Grup 2 ve 3 karşılaştırıldığında p=1 olup istatistiksel olarak anlamsızdı. Grup 1 abdominal duvar ve karın içi organlar arasındaki en yüksek adezyon skoru sergiledi.
Yöntem:
Otuz rata laparatomi yaptık ve bu ratlarda scraping model oluşturarak postoperatif intraabdominal adezyonu indükledik. Hayvanları rastgele 10 rattan oluşan 3 eşit gruba ayırdık. Kontrol grubu olan grup 1’e sadece çekal abrazyon oluşturup herhangi bir madde uygulamadık. Grup 2’ye çekal abrazyonu takiben hyalurinik asitli adezyon bariyeri uyguladık. Grup 3’e çekal abrasyonu takiben COE uyguladık.
Amaç:
Abdominal cerrahi girişimler sonrası gelişebilen intraabdominal adezyonlar halen ciddi morbidite ve mortaliteye yol açmaktadır. Biz bu çalışmada hyaluronik asitli adezyon bariyeri ile Calendula officinalis ekstraktının (COE) deneysel adezyon modeli oluşturduğumuz ratlardaki adezyon önleyici etkisini araştırıp karşılaştırmayı amaçladık.
Anahtar Kelimeler:
Calendula officinalis, hyalurinik asit, postoperatif intra-abdominal adezyon, scraping model
Kaynaklar
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