ABSTRACT

Liver metastasis is detected in significant number of patients with colorectal carcinoma at or after the time of diagnosis. Aim of our study is to evaluate general survival outcome and factors effecting survival of colorectal cancer patients with liver metastasis.

Patients who underwent operation for colorectal carcinoma with liver metastasis that is detected at or after time of diagnosis were included in our study. Information about patients were recorded from patient files retrospectively.

Our study involve 69 patients. Synchronous metastasis was detected in 69.5% of patients (48), metachronous metastasis was detected in 30.5% of patients (21). Right hepatectomy performed to three patients, left hepatectomy to one patient and liver metastasectomy to 31 patients. Radiofrequency ablation therapy was performed to five patients. To two of patients chemoembolisation was done. Lung resection was performed to one patient because of detection of lung metastasis at follow up. 65% of patients (45) have died. Survival is negatively effected in patients with four or more lymph node metastasis (p=0.008). Poor survival was detected in two or more metastatic segment existence, metastasis detected with more than 5 cm in diameter, patients with synchronous metastasis and patients with unresectable metastasis.

Survival ratio is related with metastatic segment count and diameter of metastasis in colorectal carcinoma patients with liver metastasis.