ABSTRACT

INTRODUCTION:

The use of curcumin that known the protectional effect on such as brain, spinal cord, heart etc. from ischemia and reperfusion injury as a pharmacological agent in experimental intestinal ischemia reperfusion model on rats and to investigate the effects of it.

METHODS:

We used 24 Wistar-Albino rats. We composed 3 groups each containing 8 rats. Rats in sham group were sacrified 105 minutes observation after laparotomy. Sixty minutes reperfusion was performed following 45 minutes ischaemia in control group. We performed the study group by administration of 100 mg/kg curcumin intraperitoneally. We sacrified all of the rats by taking blood samples to evaluate of the lactate after resection of ileum for detecting tissue malondialdehid, superoxide dismutase, glutatione activities and histopathological evaluation.

RESULTS:

Lactate and MDA levels were significantly higher in control and study groups than sham group (P<0.001). These levels were significantly lower in study groups. In Sham group SOD and GSH activities were higher. In control group these activities were statistically lower. Although definitive cell damage was determinated in the control group, the damage in the study groups observed lower in different levels.

DISCUSSION AND CONCLUSION:

Administration of curcumin reduced the ischemia-reperfusion injury at small intestine.