E-ISSN: 2536-4901 ISSN: 2536-4898
Anal Fissure and High Dose Botulinum Toxin: A Pilot Study of 11 Patients
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Research Article
VOLUME: 23 ISSUE: 1
P: 24-30
March 2013

Anal Fissure and High Dose Botulinum Toxin: A Pilot Study of 11 Patients

Turk J Colorectal Dis 2013;23(1):24-30
Hovsep Hazar
1. Medica Medical Center, Istanbul, Turkey
No information available.
No information available
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ABSTRACT

INTRODUCTION:

To investigate the results of high dose botulinum toxin injection as an alternative to surgery for the medical treatment refractory anal fissure.

METHODS:

11 patients were each injected 90 units of botulinum toxin in 2008-2012. Early (hematoma formation, infection) and late (temporary incontinence) complications, epithelialization of fissure and recurrence rates are noted.

RESULTS:

Neither early nor late complications were encountered. Fissures healed in all of the 11 patients, one recurrence was observed in six months.

DISCUSSION AND CONCLUSION:

High dose botulinum toxin injection to anal sphincters is safe and achieves a high success rate for the treatment of anal fissure. If these results can be confirmed by a randomized trial, high dose botulinum toxin injection treatment may become an alternative for surgery or even the first line treatment for chronic anal fissure.

Keywords:
Anal Fissure, Botulinum Toxin